Wayne Sossin, PhD
Wayne Sossin is interested in the cellular and molecular events that shape brain function.听Sossin has proposed that memories are stored using specialized synapses that can be distinguished by their molecular constituents. This proposal is being examined both in the simple nervous system of Aplysia, where behavioural memory is encoded by changes in the synaptic strength of identified neurons and in rodent models where powerful genetic tools allows for detailed correlations between molecular changes and behavior. Sossin also is interested in neurodevelopmental disorders and the role that local protein synthesis in neurons plays in the origin and regulation of these disorders. 听
Zha C, Farah CA, Holt RJ, Ceroni F, AlAbdi L, Thuriot F, Khan AO, Helaby R, L茅vesque S, Alkuraya FS, Kraus A, Ragge N,听Sossin WS.听Biallelic variants in the small optic lobe calpain CAPN15 are associated with congenital eye anomalies, deafness and other neurodevelopmental deficits.听Hum. Mol. Genet.听29: 3054-3063听
Sossin WS听and Costa-Mattioli M (2018) Translational Control in the Brain in Health and Disease.听Cold Spring Harbor Perspectives in Biology听doi: 10.1101/cshperspect.a032912听
Sossin WS听(2018) Memory synapses are distinguished by distinct molecular complexes: A proposal.听Frontiers in Synaptic Neuroscience听doi: 10.3389/fnsyn.2018.00005.听
Hu J,听Ferguson L, Adler K,听Farah CA, Hastings MH,听Sossin WS, Schacher S. (2017) Selective erasure of distinct forms of long-term synaptic plasticity underlying different forms of memory in the same postsynaptic neuron.听Current Biology,听27(13):1888-1899.e4.听
Graber TE, Hebert-Seropian S, Khoutorsky A, David, A Yewdell JW, Lacaille J-C,听Sossin WS. (2013) Reactivation of stalled polyribosomes in synaptic plasticity.听PNAS.听Oct 1;110(40):16205-10.听
