Now in its 28th听year, Qu茅bec Science magazine鈥檚 annual list of top 10 scientific discoveries in celebrates breakthrough research being done in Quebec. This year, a pair of 平特五不中-led initiatives 鈥� both focussing on brain cancer 鈥� have made the list.
鈥淟ively, diverse, surprising: This is how we could describe research in Quebec in a few words,鈥� said the editors of the magazine in听, noting that each year, Quebec researchers publish more than 17,000 studies.
The Top 10 list was selected by a jury of scientists and journalists. The one caveat: None of the discoveries in this year鈥檚 list involve COVID-19 as a number of studies are still underway.
As per tradition, Qu茅bec Science鈥檚 top discovery of 2020 will be chosen by the voting public. Visit听听to see the top 10 discoveries and to vote for your favourite.
While both 平特五不中 discoveries involve research into brain cancer and fall under the same item on the Qu茅bec Science list (鈥淚ncursion in茅dite dans les tumeurs du cerveau鈥�), they are independent of each other.
Deconstructing glioblastoma complexity reveals its pattern of development
Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumour. A study led by Drs.听Kevin Petrecca, a neurosurgeon and brain cancer researcher at The Neuro (Montreal Neurological Institute and Hospital) of 平特五不中; and Charles Couturier, a neurosurgery resident, has uncovered a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth.
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Drs. Kevin Petrecca (right) and Charles Couturier
The study, which is the largest ever single cancer cell RNA sequencing project, included 55,000 glioblastoma cells and 20,000 normal brain cells. The team found that there are five main cancer cell types within each tumor, and these cancer cell types are similar to the cell types that are in the normal human brain.
For the first time, researchers detected what they describe as a progenitor glioblastoma stem cell (GSC) 鈥� a cell type from which all other cancer cells develop. They showed a cellular hierarchical organization to the cancer which originates from progenitor GSCs.
After identifying molecular vulnerabilities in progenitor GSCs, the researchers then targeted these and found that progenitor GSC survival and proliferation decreased as a result. In preclinical disease models, this reduced tumor growth and increased survival.
鈥淥ur work has gone a long way to resolve the complexity of glioblastoma heterogeneity, and provides a new framework to reconsider the nature of glioblastoma,鈥� said Dr. Petrecca when the听study first came out. 鈥淯nderstanding how these cancer cells interact with the cancer microenvironment is not well understood in this disease, but this study serves as a good starting point to begin to understand how glioblastoma originates and evolves prior to treatments.鈥�
Editor鈥檚 note: Dr. Petrecca and Fr茅d茅ric Leblond of Polytechnique Montr茅al won Qu茅bec Science鈥檚听听for developing a cancer-detection probe.
Identifying the cellular origins of pediatric brain tumours
Progenitor cells are also key to the research being done by a team led by听, an investigator at the Lady Davis Institute at the Jewish General Hospital and听, of the Research Institute of the 平特五不中 Health Centre (RI-MUHC).
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Drs. Claudia Kleinman (left) and Nada Jabado
The team, along with Dr. Michael Taylor of The Hospital for Sick Children (SickKids), discovered that several types of highly aggressive and, ultimately, fatal pediatric brain tumors originate as a result of stalled development of progenitor cells in the pons and forebrain. The genetic event that triggers the disease happens in the very earliest phases of cellular development, most likely prenatal.听Rather than developing normally, the cells鈥� progress is halted and they transform into malignancies.
The condition is called Peter Pan Syndrome as these cells are in a state of arrested development. The challenge for researchers has been to identify how best to 鈥渦nlock鈥� these cells and allow for normal development.
Applying sophisticated single cell sequencing techniques and large-scale data analysis, researchers compiled the first comprehensive profile of the normal prenatal pons, a major structure on the upper part of the brainstem that controls breathing, as well as sensations including hearing, taste, and balance.
鈥淭he cornerstone to fighting these conditions is to identify the biological process at work, which is what our research has achieved,鈥� said Dr. Kleinman when the听study first came out.听鈥淥nce we understand the underlying mechanisms, the search can begin for the means to unblock the arrested development of the cells. The complexity of the brain is astounding, and we now have narrowed down where to search.鈥�
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This article was originally posted in the听
