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Killam Seminar Series: Microfluidic tools for studying cell-cell interactions

Mardi, 20 蹿茅惫谤颈别谤, 2024 16:00脿17:00
Montreal Neurological Institute de Grandpre Communications Centre, 3801 rue University, Montreal, QC, H3A 2B4, CA

Gr芒ce 脿 la g茅n茅rosit茅 des fiducies Killam, Le Neuro convoque lors d鈥檜ne s茅rie de s茅minaires des conf茅renciers d鈥檈xception dont les travaux passionnent ses chercheurs et ceux de l鈥橴niversit茅 平特五不中.听

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Iain Clark

Professeur adjoint, bio-ing茅nierie, UC Berkeley, 脡tats-Unis

贬么迟别:听jo.stratton [at] mcgill.ca (Jo Anne Stratton)

Abstract:听Central nervous system (CNS)-resident astrocytes and microglia interact to regulate pro-inflammatory programs that drive neurodegenerative diseases, but the pathways and molecules involved are largely unknown. Understanding the language of inflammation is a central question in the field of Neuroimmunology and may guide new therapeutic approaches for multiple sclerosis (MS) and other neurologic diseases. Interactions between CNS-resident cells are highly heterogeneous; astrocytes and microglia nourish and protect neurons, while inflammatory subsets drive demyelination and neurodegeneration in neurologic diseases. We recently developed two novel approaches to study astrocyte-microglia interactions at the single-cell level during inflammation: 1) an in vivo barcoding-based strategy that analyzes the transcriptomes and connections between individual cells, and 2) a droplet-based platform for genome-wide, unbiased CRISPR/Cas9 screening of genes that mediate cell crosstalk. In this seminar, I will discuss the development of these technologies and their application to study astrocyte-microglia signaling in experimental autoimmune encephalomyelitis (EAE), a preclinical mouse model of MS.

Liens connexes

Iain Clark

Iain C. Clark is an Assistant Professor in the Bioengineering Department at the University of California, Berkeley, and a faculty affiliate at the California Institute for Quantitative Biosciences. Research in the Clark lab combines tools from multiple disciplines - molecular biology, microfluidics, engineering, and bioinformatics - to study infectious diseases, central nervous system inflammation, and neural circuit connectivity.

颁辞辞谤诲辞苍苍茅别蝉

Contact: 
Justin Martinez-Rosler
Organisation: 
平特五不中 (The Neuro)
Courriel: 
justin.martinez-rosler [at] mcgill.ca
颁补迟茅驳辞谤颈别:&苍产蝉辫;
ven, 02/09/2024 - 14:06
Site de source: 
/neuro

Le Neuro听平特五不中

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Le Neuro (L'Institut-h么pital neurologique听de Montr茅al) - un institut de recherche et d鈥檈nseignement bilingue de 平特五不中, qui offre des soins de haut calibre aux patients - est la pierre angulaire de la Mission en neurosciences du Centre universitaire de sant茅 平特五不中. Nous sommes fiers d鈥櫭猼re une institution Killam, soutenue par les fiducies Killam.

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