平特五不中

Now, researchers from 平特五不中 and Concordia University in Montreal have investigated, possibly for the first time in any species, the direct impact of pain on sexual behaviour in mice. Their study, published in the April 23 issue of The Journal of Neuroscience, found that pain from inflammation greatly reduced sexual motivation in female mice in heat -- but had no such effect on male mice.

聽鈥淲e know from other studies that women鈥檚 sexual desire is far more dependent on context than men鈥檚 鈥� but whether this is due to biological or social/cultural factors, such as upbringing and media influence, isn鈥檛 known,鈥� says Jeffrey Mogil, a psychology professor at 平特五不中 and corresponding author of the new study. 鈥淥ur finding that female mice, too, show pain-inhibited sexual desire suggests there may be an evolutionary biology explanation for these effects in humans 鈥� and not simply a sociocultural one.鈥�

To conduct the study, the researchers placed mice in a mating chamber divided by a barrier with openings too small for male mice to squeeze through. This enabled the females to decide whether, and for how long, to spend time with a male partner. Female mice in pain spent less time on the 鈥渕ale side鈥� of the testing chamber, and as a result less sexual behaviour occurred. The researchers found that the sexual motivation of the female mice could be revived, however with a pain-relieving drug (pregabalin) or with either of two known desire-enhancing drugs.

Male mice, for their part, were tested in an undivided chamber in which they had free access to a female partner in heat. Their sexual behaviour was entirely unaffected by the same inflammatory pain. There were no differences in pain perception between the sexes, the researchers determined.

聽鈥淐hronic pain is very often accompanied by sexual problems in humans,鈥� says Prof. Yitzchak Binik, a professor of psychology at 平特五不中 and Director of the Sex and Couple Therapy Service at the 平特五不中 Health Center. 鈥淭his research provides an animal model of pain-inhibited sexual desire that will help scientists study this important symptom of chronic pain.鈥�

Melissa Farmer, now a postdoctoral fellow at Northwestern University, led the study as a doctoral student at 平特五不中 under the supervision of Prof. Mogil, a pain researcher, and Prof. Binik, a human sexual-disorder researcher.

Prof. James Pfaus of Concordia University鈥檚 Centre for Studies in Behavioral Neurobiology, an expert on rodent sexual behaviour, also co-authored the study.聽 鈥淭he sex differences in pain reactivity open new doors to understanding how sexual responses are organized in the brain,鈥� Prof. Pfaus said. 鈥淚n fact, the growing trend towards personalized medicine requires us to understand how particular ailments, along with their treatments, might impact the sexual lives of women and men.鈥�

The work was supported by a National Research Service Award from the U.S. National Institutes of Health, by the Louise and Alan Edwards Foundation, and by a Pfizer Pain Research Award from Pfizer Canada Inc.

鈥淧ain Reduces Sexual Motivation in Female But Not Male Mice鈥�, Melissa A. Farmer et al. The Journal of Neuroscience, April 23, 2014.