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平特五不中 Professor earns Quebec鈥檚 highest honour for research in biomedicine

Professor William Foulkes awarded 2020 Wilder-Penfield Prize for research in the genetics of breast and ovarian cancer, helped in part by Quebec鈥檚 鈥榝ounder effect鈥
Published: 4 November 2020

Earlier today, the Quebec government announced the winners of its annual Prix du Quebec competition, a series of 15 awards in science and culture. Among them was Professor William Foulkes, Head of the Cancer Genetics Laboratory at the Lady Davis Institute, a member of the Cancer Research Program of the Research Institute of the 平特五不中 Health Centre, and Director of the Program in Cancer Genetics at 平特五不中. Dr. Foulkes won the Wilder-Penfield prize for biomedicine, in part due to his extensive research not only into the genetic roots of breast and ovarian cancer, particularly in Quebec, but also for his work on rare forms of cancer.

鈥淲inning this award is extremely important, both professionally and personally,鈥 said Dr. Foulkes. 鈥淚 chose to live in Quebec almost 25 years ago, and to be recognized in this way by my adoptive home is very gratifying.鈥

During his career, Dr. Foulkes identified the specific genetic mechanisms involved in several inherited cancers. According to the Canadian Cancer Society, inherited cancers account for 5 to 10% of all cancers. Women who inherit the BRCA1 or BRCA2 genes, for example, are up to 10 times more likely to develop breast cancer than the average woman. Identifying these and other genes has opened new avenues to interventions that have saved lives across Canada.

One of the elements of his research success has been the genetic environment that Quebec鈥檚 population offers. Known as the 鈥渇ounder effect,鈥 it can reveal genetic components that are more pronounced than in other Canadian communities. Dr. Foulkes has also put Quebec on the map for other researchers 鈥 in 2005 he helped establish the International Symposium on Hereditary Breast and Ovarian Cancer, which has been running biennially since then and attracts hundreds of delegates to each edition.

鈥淭his recognition of Dr. Foulkes鈥檚 contribution to Quebec is so well deserved,鈥 said Martha Crago, Vice-Principal, Research and Innovation. 鈥淗is work to identify the genes and mutations that cause breast cancer has saved many lives. His award has very special significance to me. His tenacity to identify a family breast cancer gene that had killed multiple generations in my family was remarkable. So many women owe him a huge debt, and this prize is a small symbol of his tremendous impact.鈥

Dr. Foulkes is a model academic, with over 600 published articles and many of these are highly respected 鈥 and referenced 鈥 by his peers. One of his key papers on the 鈥渂asal-like鈥 nature of BRCA1-related breast cancer has been cited 600 times. Dr. Foulkes is more than a researcher, however. Throughout his numerous discoveries and contributions, he has also maintained clinical practice, demonstrating his concern for patient well-being.

鈥淚 am always motivated by my clinical work with patients,鈥 explained Dr. Foulkes. 鈥淚t is often the source of new insights and discoveries that in turn become interventions that can help them, their families, and other persons. It鈥檚 a highly rewarding cycle.鈥

The Prix du Quebec was created in 1977 to honour cultural and scientific achievement. Previous winners of the Wilder-Penfield prize from 平特五不中 include Drs Charles Scriver, F. Clarke Fraser, Philippe Gros, Guy Rouleau and Nahum Sonenberg.

About 平特五不中

Founded in Montreal, Quebec, in 1821, 平特五不中 is a leading Canadian post-secondary institution. It has two campuses, 11 faculties, 11 professional schools, 300 programs of study and some 38,000 students, including 8,800 graduate students. 平特五不中 attracts students from over 150 countries around the world, with more than 7,700 international students making up 20 percent of the student body. Almost half of 平特五不中 students claim a first language other than English, including 38 per cent who claim French as their first language.

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