Major funding awarded to RI-MUHC scientists for innovative genomics geared to Quebec patients
Pioneering work to advance genomics and precision health treatments at the Research Institute of the 平特五不中 Health Centre (RI-MUHC) has been rewarded by G茅nome Qu茅bec. Dr. Nada Jabado and Dr. Ruth Sapir-Hichhadze, the RI-MUHC scientists who received the reward, were among the winners of a nation-wide competition emphasizing precision treatments in genomics.
received $13 million in funding after emerging as one of the four winning projects in Quebec in Genome Canada鈥檚 2017 Large-Scale Applied Research Project Competition Genomics and Precision Health. A total of $58 million was distributed to projects across the province.
鈥淭hese major investments see Quebec established as a centre of innovation that will provide a major benefit to Quebec patients, who will have access to the best health care thanks to this technology. Congratulations to the winning teams who are ensuring genomics will be more accessible to citizens and the larger population than ever before,鈥� says G茅nome Qu茅bec President and CEO Daniel Coderre.
Brain cancer: Improving the chances of survival and the quality of life for children
Dr. Jabado鈥檚 team from the Child Health and Human Development Program at the RI-MUHC were rewarded for their personalized therapy approach to childhood brain cancer, which is the leading cause of cancer-related deaths among children under age听20. The team 鈥� led by Dr. Jabado alongside colleagues Dr. Jacek Majewski (平特五不中/RI-MUHC) and Dr. Michael Taylor (SickKids) 鈥� has fast-tracked treatments targeting specific genetic alterations at diagnosis.
鈥淏rain cancer remains a lethal and disabling disease. As researchers we have to pursue our efforts in finding innovative ways to improve survival and quality of life for children and young adults, during and after treatment,鈥� says Dr. Jabado, a pediatric hemato-oncologist at the Montreal Children鈥檚 Hospital of the MUHC and a professor of Medicine at 平特五不中.听
Building on their track record of cutting-edge research, the team will use innovative technologies to study the genetics of brain tumours down to investigations at the single-cell level. Their aim is to uncover new alterations in the genetic makeup of these tumours and identify specific vulnerabilities that may be targets for therapy. They will continue working closely with other clinician-scientists, healthcare providers, and policy makers to provide more rapid bedside treatment 鈥� bridging the gap between bench and clinic 鈥� with the ultimate goal of improving overall survival and the quality of life for children and young adults diagnosed with brain cancer.
Preventing rejection and loss of kidney transplants
Dr. Ruth Sapir-Pichhadze, meanwhile, is a principal co-scientist on a $9.7 million 听AMR causes premature loss of the transplant kidney in as many as 30 per cent of transplant recipients, prompting a return to dialysis and 鈥� often 鈥� early death. Dr. Sapir-Pichhadze鈥檚 team at the RI-MUHC鈥檚 Centre for Outcomes Research and Evaluation focus their efforts on improving the matching of donors and recipients, exploring a more personalized drug treatment, and establishing better engagement with patients and stakeholders. The study hopes to reduce healthcare burden and costs, improve survival rates and quality of life, and improve care for major chronic disease in Canada.
鈥淭he use of a multi-faceted approach that optimizes donor and recipient compatibility speaks to the strength of our program as it mitigates the risk of rejection by tapering surveillance and treatment to individual patient needs. Importantly, we actively engage patients and stakeholders, verify societal acceptance and cost effectiveness with the hope of implementing the lessons nationally,鈥� says Dr. Sapir-Pichhadze, a scientist from the Metabolic Disorders and Complications Program at the RI-MUHC. She is also an assistant professor of Medicine for the Division of Nephrology and Multi-Organ Transplant Program at 平特五不中. 颅
鈥淲e are very proud and excited to be supporting these two very forward looking research teams who are strongly patient oriented and are听using cutting-edge science to improve care. This is the very essence of what we are aiming for at the RI-MUHC,鈥� says Dr. Bruce Mazer, executive director and chief scientific officer of the Research Institute of the MUHC (Interim).
Professor Bartha Maria Knoppers, a Canada Research Chair in Law and Medicine and director of the Centre of Genomics and Policy at 平特五不中鈥檚 Faculty of Medicine, and her colleagues were also awarded $ 4 million .
The work of Dr. Jabado, Dr. Sapir-Pichhadze and Prof. Knoppers is among 15 new genomics and precision health projects receiving investment of approximately $162 million from Genome Canada, in collaboration with the Canadian Institutes for Health Research and project co-funding partners such as G茅nome Quebec and Genome British Columbia. These projects 鈥� spanning multiple disease areas 鈥� demonstrate how genomics-based research can contribute to a more evidence-based approach to health and thereby improve health outcomes for patients, as well as enhance the cost-effectiveness of Canada鈥檚 healthcare system.
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produced by G茅nome Qu茅bec presenting the four winning projects in Quebec.
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The Research Institute of the 平特五不中 Health Centre (RI-MUHC) is a world-renowned biomedical and healthcare research centre. The Institute, which is affiliated with the Faculty of Medicine of 平特五不中, is the research arm of the 平特五不中 Health Centre (MUHC) 鈥� an academic health centre located in Montreal, Canada, that has a mandate to focus on complex care within its community. The RI-MUHC supports over 420 researchers and close to 1,200 research trainees devoted to a broad spectrum of fundamental, clinical and health outcomes research at the Glen and the Montreal General Hospital sites of the MUHC. Its research facilities offer a dynamic multidisciplinary environment that fosters collaboration and leverages discovery aimed at improving the health of individual patients across their lifespan. The RI-MUHC is supported in part by the Fonds de recherche du Qu茅bec 鈥� Sant茅 (FRQS). .
