平特五不中

The findings, which will be published in the journal Applied and Environmental Microbiology, suggest that combining maple syrup extract with common antibiotics could increase the microbes鈥� susceptibility, leading to lower antibiotic usage. Overuse of antibiotics fuels the emergence of drug-resistant bacteria, which has become a major public-health concern worldwide.

Prof. Nathalie Tufenkji鈥檚 research team in 平特五不中鈥檚 Department of Chemical Engineering prepared a concentrated extract of maple syrup that consists mainly of phenolic compounds. Maple syrup, made by concentrating the sap from North American maple trees, is a rich source of phenolic compounds.

Not just for those with a sweet tooth

The researchers tested the extract鈥檚 effect in the laboratory on infection-causing strains of certain bacteria, including E. coli and Proteus mirabilis (a common cause of urinary tract infection). By itself, the extract was mildly effective in combating bacteria. But the maple syrup extract was particularly effective when applied in combination with antibiotics. The extract also acted synergistically with antibiotics in destroying resistant communities of bacteria known as biofilms, which are common in difficult-to-treat infections, such as catheter-associated urinary tract infections.

鈥淲e would have to do in vivo tests, and eventually clinical trials, before we can say what the effect would be in humans,鈥� Tufenkji says. 鈥淏ut the findings suggest a potentially simple and effective approach for reducing antibiotic usage. I could see maple syrup extract being incorporated eventually, for example, into the capsules of antibiotics.鈥�

The scientists also found that the extract affects the gene expression of the bacteria, by repressing a number of genes linked with antibiotic resistance and virulence.

All maple syrup samples used in the study were purchased at local markets in Montreal, then frozen until the beginning of each experiment, which involved a series of steps to produce the phenolic-rich extract.

Tufenkji, who holds the Canada Research Chair in Biocolloids and Surfaces, has also studied the potential for cranberry derivatives to fight infection-causing bacteria. The new study is co-authored by postdoctoral fellows Vimal Maisuria and Zeinab Hosseinidoust.

Funding for the research was provided by the Natural Sciences and Engineering Research Council of Canada and the Canada Research Chairs program.

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"Polyphenolic Extract from Maple Syrup Potentiates Antibiotic Susceptibility and Reduces Biofilm Formation of Pathogenic Bacteria," by Vimal B. Maisuria, Zeinab Hosseinidoust, and Nathalie Tufenkji, is scheduled for publication in Applied and Environmental Microbiology, Volume: 81 Issue: 11. To view the accepted manuscript:

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PHOTO: Vimal Maisuria (left) and Nathalie Tufenkji in the lab. CREDIT: 平特五不中

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