Research in the domain of Decision-Making and Clinical Reasoning aims to increase our understanding of the processes clinicians, teachers and educational policy-makers use to make decisions. Investigations in this domain focus on some of the following questions: What sources of information do teachers draw upon to make instructional decisions? How do clinicians use evidence to inform their teaching and assessment practices? How do findings from evidence-based medicine influence the clinical decision-making process? What role do ambiguity and/or uncertainty play in clinical reasoning? How is clinical reasoning defined and conceptualized across the different health professions? Scholarship in this area has direct implications for ensuring that learners are well prepared and competent to provide effective and safe patient care and for designing teaching and assessment interventions to support various stakeholders in their decision-making processes.