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Event

CFTRc seminar - Dr. Deborah Baines

Tuesday, January 18, 2022 11:00to12:00

Dr. Deborah Baines

Professor of Molecular Physiology, Infection and Immunity Research Institute, St George's University of London

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Talk title:Ìý‘â¶Ä™Interrogating the constituents of airway surface liquid/sputum - friends and foesÌý.’’

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The lungs are lined with a thin film of airway surface liquid (ASL) which contains a complex array of molecules that play a key role in innate defence and mediate communication between the epithelium, the immune cells, and the external environment. The ASL contains hundreds of proteins. Proteases and anti-proteases present in the ASL regulate the cleavage of these proteins and the generation of peptides. Our investigation of the sputum peptidome from people with and without Cystic Fibrosis (CF) has identified novel peptides with cellular, antimicrobial and antiviral bioactivity. In CF disease, changes to the relative abundance of proteases, anti-proteases and their activity alter the proteomic and peptidomic profile of sputum and modify the ion transport properties of the airway epithelium in vitro.

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This seminar will be given online via Zoom. Details in attached poster.

Supported by:

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ƽÌØÎå²»ÖÐ is situated on the traditional territory of the Kanien’kehà:ka, a place which has long served as a site of meeting and exchange amongst nations. We recognize and respect the Kanien’kehà:ka as the traditional custodians of these lands and waters.

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