Dr. John Antoniou
- Professor of Surgery
- Research Director
- Director of Arthroplasty Fellowship Program
MD, PhD, FRCSC
Are you currently supervising students? YES
Are you looking to recruit new students?聽
Looking to hire a Postdoctoral fellow?
- Outcome of Total Hip & Knee Arthroplasty
- Biological Repair Strategies for Aging Discs Using Autologus Mesenchymal Stem Cells & Growth Factors
- Biological Repair Strategies for Osteoarthritic Cartilage Using Growth Factors
Clinical and basic science investigation of aging and degeneration of the musculoskeletal system
Hip & Knee Adult Reconstruction
- Tissue engineering of the intervertebral disc
- Quantitative magnetic resonance imaging as a diagnostic tool of intervertebral disc degeneration
- Periprosthetic osteolysis in total hip arthroplasty
Low back pain is a disorder afflicting the elderly population and in which, intervertebral disc degeneration plays a major role. Thus, my first research goal consists in engineering a replacement nucleus pulposus tissue using a hudrogel with differentiated adult mesenchymal stem cells. Furthermore, we believe that detecting and quantifying non-invasively the matrix and biomechanical changes in disc degeneration is key to treating this disease at its early stage. We believe that quantitative Magnetic Resonance Imaging is such a tool. Finally, my third main research interest is the study of periprosthetic osteolysis and wear debris in hip bearings. Joint replacement surgery is the most effective therapy to treat the pain and disability of patients with osteoarthritis. Metal-on-metal articulations are attractive but generate wear particles. We are thus analyzing the oxidative stress and metal ions in blood of patients with metal-on-metal hip bearings to better understand the clinical relevance of raised blood metal ions in patients with these bearings.
