Pnina Brodt (PhD)
- Professor - Department of Surgery
- Associate Member - Department of Medicine
PhD
Currently supervising students
1. Role of the IGF-1 receptor in liver metastasis: signaling and crosstalk with the microenvironment.
2. The pro-metastatic microenvironment of the liver: role of inflammation.
3. Developing and IGF Trap for prevention of cancer growth and metastasis.
Metastasis, Colon Cancer, Breast Cancer, Inflammation, IGF, Targeted Cancer Therapeutics
Dr. Pnina Brodt, is a Professor in the Departments of Surgery, Medicine and Oncology at 平特五不中 and the 平特五不中 Health Center where she has been since 1983.
Dr. Brodt鈥檚 research work has focused on the biology of cancer metastasis, particularly the molecular events that underlie the process of liver metastasis. In the course of this work, Dr Brodt鈥檚 team identified the inflammatory response as a participant in the early stages of liver metastasis and showed that an inflammatory microenvironment promotes liver metastasis of colon and lung cancer. Her group has played a leading role in identifying the important role of the IGF axis in cancer invasion and metastasis. This work led to the development of several strategies for blockade of the IGF-I axis including, most recently, the bio-engineering of an IGF-Trap that is currently being developed as an anti-cancer drug.
Dr. Brodt is a co-leader of the Cancer Axis of the Research Institute of the 平特五不中 Health Center and a co-founder of the Liver Metastasis Research Network () 鈥� a multidisciplinary international network dedicated to uncovering the molecular mechanisms of liver metastasis for the betterment of patient care.