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The brain's structural connectome is organized to support efficient control of state transitions

Danielle Bassett, University of Pennsylvania
Tuesday September 21, 12-1pm
Zoom Link: 

´¡²ú²õ³Ù°ù²¹³¦³Ù:ÌýThe human brain is a complex organ characterized by heterogeneous patterns of interconnections. Non-invasive imaging techniques now allow for these patterns to be carefully and comprehensively mapped in individual humans, paving the way for a better understanding of how wiring supports cognitive processes. While a large body of work now focuses on descriptive statistics to characterize these wiring patterns, a critical open question lies in how the organization of these networks constrains the potential repertoire of brain dynamics. In this talk, I will describe an approach for understanding how perturbations to brain dynamics propagate through complex wiring patterns, driving the brain into new states of activity. Drawing on a range of disciplinary tools – from graph theory to network control theory and optimization – I will identify control points in brain networks and characterize trajectories of brain activity states following perturbation to those points. Finally, I will describe how these computational tools and approaches can be used to better understand the brain's intrinsic control mechanisms and their alterations in psychiatric conditions.