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Guillaume Sébire

Academic title(s): 

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MD, PhDÌý

Guillaume Sébire
Contact Information
Address: 

Research Institute of the ƽÌØÎå²»ÖÐ Health CenterÌý
1001 Decarie Boulevard, Block E, M0 3211Ìý
Montreal, Quebec, H4A 3J1

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Email address: 
guillaume.sebire [at] mcgill.ca
Division: 
Neurology
Degree(s): 
  • MSc (DEA) in Neuroscience, Université Paris VI, France. Research project: Regulation of production, cellular targets, and roles of cytokines within the central nervous system. Director: Professor Marc Tardieu, MD, PhD Prize of the Société Francophone de Recherche en Pédiatrie, 1990Ìý
  • MD and residency in pediatrics and neurology: Diplôme d'études spécialisées (DES) de Pédiatrie and Pediatric neurology, Université de Paris. Medical thesis: Disorders of neuronal migration, Université Paris V, France, 1991 (Director: Docteur Jean Aicardi), 1991Ìý
  • Clinical and Research Fellowship (Chef de clinique), Division of Neurology, Department of Pediatrics, CHU Bicêtre, Université Paris XI France. Training in pediatric neuroinflammatory diseases (Director: Pr Marc Tardieu), and pediatric neurovascular disease (Director: Pr Pierre Lasjaunias), 1993-1997
  • PhD in Neuroscience, Université Paris VI, France. Regulation of production, cellular targets, and roles of cytokines within the central nervous system. Director: Professor Marc Tardieu, 1995Ìý
Biography: 

Dr. Guillaume Sebire completed all of his medical and scientific training in the old continent at the cross road of pediatrics, neurology and immunology in Université de Paris, France. He started his career at Université catholique de Louvain in Belgium, before jumping over the ocean to Canada 15 years ago to ally the best of the two worlds and reach a somehow fruitful balance between sometimes competing clinical, teaching and research interests.Ìý

The source of inspiration of his lab directly arises from the kids that he provides cares to, or more exactly from frustrating limitation of cares, and from serendipitous clues of discoveries sensed by humble but curious and careful observations of poorly known conditions encountered during the day to day work as pediatric neurologist. Dr. Sebire believes that any patient has the power to inspire brand new pieces of knowledge to be validated by further research.ÌýÌý

The Department of Pediatrics, its members and research facilities, is the ideal milieu to nurture his research.Ìý

Areas of expertise: 
  • Our lab focus on elucidating the hidden inflammatory processes underlying neurodevelopmental conditions, such as cerebral palsy, autism, stroke, or encephalitis.Ìý
  • One of the main strength of our lab is to build pertinent preclinical animal models inspired from patients’ reality to mimic the complex scenarios underlying kids’ brain diseases from obscure origin, and take advantage of these models to further understand their mechanisms, and to uncover new diagnostic markers and neuroprotective treatments.Ìý

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Areas of interest: 
  • Characterize causes, clinical manifestations, and treatment of stroke in childhoodÌý
  • Elucidate the mechanisms of infectious/inflammatory aggressions affecting the placenta and the developing brain and responsible for handicaps, such as cerebral palsy, learning disabilities and behavioural disorders such as autism or ADHDÌý
  • Diagnostic criteria, and differential diagnosis of infantile abusive head injuriesÌý
Awards, honours, and fellowships: 
  • Nestlé-Guigoz (doctoral grant), France, 1989-1990Ìý
  • Prix de la « Société Francophone de Recherche en Pédiatrie », 1990Ìý
  • ANRS (Agence Nationale de Recherche contre le SIDA, France), doctoral grant, France, 1991-1993Ìý
  • Bourse Fondation Valérie Chamaillard, Fondation de France, 1997Ìý
  • INSERM (poste d’accueil), contrat résilié, nomination UCL, France, 1997Ìý
  • Bourse salariale « Clinicien Chercheur Boursier Junior 2 », FRSQ (Fond Recherche Santé Québec), $80,000, 2005-2007Ìý
  • Prix d’excellence de la recherche en pédiatrie, Foundation of Stars, Québec, Canada, 2006Ìý
  • Bourse salariale « Clinicien Chercheur Boursier senior », FRSQ (Fond Recherche Santé Québec), $100,000, 2007-2010Ìý
  • Bourse salariale « Chercheur National » FRSQ (Fond Recherche Santé Québec), $120,000, 2010-2014Ìý
  • Prix de la recherche de la Fondation des Maladies du CÅ“ur Jonathan Ballon/Heart and Stroke Foundation (HSF), Canada, $10,000, 2014Ìý
  • James Edmund Dodds Chair of Pediatrics, ƽÌØÎå²»ÖÐ, 2014-2019, 2019-Ìý

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