/oss/taxonomy/term/7292/all en /oss/article/medical-contributors/leptin-hormone-regulate-appetite <p>The implementation of glucagon-like peptide-1 (GLP-1)-based drugs for the treatment of obesity has been an incredible advance in the field, enabling up to 25% decreases in body weight in many patients. However, GLP-1 is only one of many factors in the body that regulate appetite. So why are some of these other hormones not also being used to treat overweight and obesity? The answers are sometimes surprising, as exemplified by the focus today on leptin.</p> Fri, 08 Mar 2024 14:11:35 +0000 Patricia Brubaker, Ph.D., F.R.S.C. 9859 at /oss /oss/article/medical-health-and-nutrition/what-next-evolution-glp-1-based-therapies-diabetes-and-obesity <p>The first glucagon-like peptide-1 (GLP-1)-based therapeutic was approved by Health Canada in 2011 for the treatment of hyperglycemia in patients with Type 2 diabetes. Little was it suspected at that time that this class of drugs would go on to become a global success not only for Type 2 diabetes but, now, also for people living with overweight/obesity. Since that time, numerous variants of GLP-1 have been developed, with at least 7 different forms in trials or available today.</p> Fri, 15 Dec 2023 20:17:14 +0000 Patricia Brubaker, Ph.D., F.R.S.C. 9763 at /oss