Teruko Taketo-Hosotani
Associate Professor, Department of Surgery, Division of Urology
Associate Member, Department of Obstetrics and Gynecology
Associate Member, Department of Biology
PhD
The role of sex chromosomes in female germ cell differentiation
Dr. Taketo completed her Ph.D. in Kyoto University, Japan. The topic of her thesis was the mechanism of the action of a hypertension drug, guanethidine, on the adrenergic neuron. She joined the Population Council, New York as a postdoctoral fellow and began to study gonadal sex differentiation in mammals. She became an independent scientist from 1984 to 1986.
She was recruited to 平特五不中's Deptartment of Surgery as an Assistant Professor in 1987, and was promoted to Associate Professor in 1994. During this period, her group focused听 on the cause of infertility in the B6.YTIR sex-reversed female mouse, supported by grants from MRC and CIHR. Her听 group's specific aims are:
- to clarity the mechanism of sex determination and sex reversal in the B6.YTIR mouse strain;
- to test the hypothesis that oocytes with meiotic errors are eliminated during the meiotic prophase progression in order to raise the quality of the surviving oocytes, and
- to identify the ooplasmic defects in XO and XY oocytes which impair meiotic chromosome segregation.
These studies help with the understanding of female infertility, particularly, associated with maternal age. In addition, she has been teaching the course Genetics of Mammalian Development for the Biology Department.
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