Like babies, eggs send signals when 鈥渉ungry鈥�
Now, a team at the Research Institute of the 平特五不中 Health Centre (RI-MUHC) led by scientist Dr. Hugh Clarke has found out who calls the shots when it is mealtime for the growing egg, how that cell-to-cell message is communicated and how the feeding tubes themselves are generated. It turns out the egg is in charge and its communication skills are highly sophisticated. When it鈥檚 time to get food, the egg sends signals to the tiny surrounding cells to make the feeding tubes, and as it grows and needs more nourishment, it signals them to make even more tubes.聽
These findings, which push the scope of our understanding of female fertility, were published in the April 2 print edition of Current Biology.
The study revealed that growth factors 鈥� especially one known as growth differentiation factor 9 鈥� coming from the eggs drove the feeding tube multiplication and growth process,聽 acting directly upon the genetic machinery of the follicle cells surrounding the egg. These discoveries put the spotlight directly on the egg itself, says Dr. Clarke.
鈥淚t shows that the egg is playing an active role in creating the microenvironment that it needs to continue its development,鈥� says Dr. Clarke, lead study author, who is also a senior scientist from the Child Health and Human Development Program at the RI-MUHC and a professor and research director of the Department of Obstetrics and Gynecology at 平特五不中.
鈥淲e observed that the whole process of egg development and its interaction with its environment is not static. It's very dynamic,鈥� adds first study author Stephany El-Hayek, who was a PhD student in Dr. Clarke鈥檚 lab at Glen site of the RI-MUHC at the time.
The team also found that in older mice, the cells surrounding the egg produced fewer feeding tubes. Scientists know that the eggs of older women are less successful in producing healthy babies, but they don鈥檛 know the reason why. Dr. Clarke鈥檚 research offers a new possible explanation.
Might it be because the cells surrounding the egg are not good at making enough feeding tubes as the egg grows older? The answer to that question, which Dr. Clarke鈥檚 team is now investigating, could one day lead to the possibility of increasing fertility or even retaining fertility longer into older age, says the researcher.聽聽
鈥淯nderstanding how the egg interacts with its environment will allow us to ensure that growing eggs retain their fertility,鈥� says Dr. Clarke. 鈥淏ut it could also lead to developing techniques to grow healthy eggs in the laboratory in an effort to preserve fertility in women who have cancer,鈥� says Dr. Clarke.
About the study
The study聽聽was co-authored by Stephany El-Hayek, Qin Yang, Laleh Abbassi, Greg FitzHarris, and Hugh J. Clarke.聽
This work was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health &聽Human Development of the National Institutes of Health (R21HD086407), the Canadian Institutes of聽Health Research (CIHR), and the Natural Sciences and Engineering Research Council of Canada (NSERC).
About the Research Institute of the MUHC
The Research Institute of the 平特五不中 Health Centre (RI-MUHC) is a world-renowned biomedical and healthcare research centre. The Institute, which is affiliated with the Faculty of Medicine of 平特五不中, is the research arm of the 平特五不中 Health Centre (MUHC) 鈥� an academic health centre located in Montreal, Canada, that has a mandate to focus on complex care within its community. The RI-MUHC supports over 420 researchers and close to 1,200 research trainees devoted to a broad spectrum of fundamental, clinical and health outcomes research at the Glen and the Montreal General Hospital sites of the MUHC. Its research facilities offer a dynamic multidisciplinary environment that fosters collaboration and leverages discovery aimed at improving the health of individual patients across their lifespan. The RI-MUHC is supported in part by the Fonds de recherche du Qu茅bec 鈥� Sant茅 (FRQS).聽
ILLUSTRATION:聽The image shows a growing oocyte in the middle, which is very large with a bright green rim, surrounded by many small red follicle cells whose nuclei are stained blue. The thin bright-green hair-like structures between them are the feeding tubes, which grow out from the follicle cells when they receive signals from the oocyte. This image was captured by using confocal microscopy at the Imaging Platform of the Research Institute of the 平特五不中 Health Centre, Montreal, Canada.
(CREDIT: Dr. Qin Yang, Research Associate, Research Institute of the 平特五不中 Health Centre)
