Feindel Brain and Mind Seminar Series: Steps Towards Laminar Resolution in Non-invasive Human Electrophysiology
La s茅rie Feindel Brain and Mind Seminar s鈥檌nscrit dans la ligne de pens茅e du Dr鈥疻illiam Feindel (1918-2014), directeur du Neuro de 1972 脿 1984, qui consiste 脿 maintenir un lien constant entre pratique clinique et recherche. Les pr茅sentations porteront sur les derni猫res avanc茅es et d茅couvertes en neuropsychologie, en neurosciences cognitives et en neuro-imagerie.聽
Les scientifiques du Neuro, ainsi que des coll猫gues et collaborateurs venus du milieu ou du monde entier, se chargeront des conf茅rences. Cette s茅rie se veut un forum virtuel pour les chercheurs et les stagiaires en vue de favoriser les 茅changes interdisciplinaires sur les m茅canismes des troubles c茅r茅braux et cognitifs, leur diagnostic et leur traitement.聽
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Saskia Helbling
Chercheuse associ茅e, Institut Ernst Str眉ngmann pour les neurosciences, Allemagne.
Chercheuse associ茅e, Institut Max Planck pour les sciences cognitives et c茅r茅brales humaines, Allemagne.
贬么迟别: christine.tardif [at] mcgill.ca (Christine Tardif)
础产蝉迟谤补肠迟:听Advances in neuroimaging and electrophysiology have enabled non-invasive investigation of human brain function at increasingly fine spatial scales. I present three interconnected research projects towards achieving laminar resolution in non-invasive human electrophysiology. First, I demonstrate how myelin-informed forward models derived from high-resolution quantitative MRI enhance MEG/EEG source reconstruction. Second, building on this structural-functional relationship, I examine the microstructural foundations of cortical speech tracking. By leveraging high-resolution cortical myelination maps, this approach offers insights into the potential laminar origins of low-frequency auditory activity and top-down modulatory signals during speech perception. Finally, I present a simulation study that investigates the potential of optically pumped magnetometers (OPMs) for inferring laminar origins of MEG signals, demonstrating the benefits of on-scalp sensors for laminar inference. These complementary approaches aim to push the boundaries of spatial resolution in non-invasive electrophysiology, offering new perspectives on cortical layer-specific activity and structure-function relationships in the human brain.
