平特五不中

Professor of Human Genetics and Theme Lead for the 平特五不中 Research Centre on Complex Traits (MRCCT), Silvia Vidal was recruited to the LSC in 2003 while it was still in the planning stages. When the doors opened in 2008, she immediately launched an ambitious collaboration that took full advantage of the new facilities.

Clinician-scientists, infectious disease specialists and computer scientists from the LSC, the 平特五不中 Health Centre, the Faculty of Science, the 平特五不中 Genome Centre, and the University of British Columbia were enlisted and the resulting project led to the discovery of a host of new mutations in mouse genes that are now being used to develop molecules to treat diseases like multiple sclerosis, Crohn鈥檚 disease, malaria, and other infectious and inflammatory diseases. It was an auspicious beginning, says Professor Vidal. 鈥淭here are only a few places in the world where it was possible to carry out this very large project, I was very lucky to have been recruited to the LSC,鈥� she says.

For Professor Vidal, the LSC鈥檚 exceptional animal facilities are at the core of its success. 鈥淭he strength of this group is using the mouse model to understand the genetic and immunological determinants of disease so that鈥檚 why for us the animal facility is so important,鈥� she explains. 鈥淣ot only is it state of the art and the animals are kept very clean and in good condition, but there are also specialized facilities which allow us to do different treatments and equipment that allow us to analyse the mouse with advanced imaging techniques that provide critical new insights on pathogenic mechanisms.鈥�

The facilities in turn attract top scientists to the LSC. Professor Vidal cites the example of Assistant Professor in Physiology Judith Mandl, who recently came to the LSC following training first in computational biology in the United Kingdom and then in systems biology and immunology at the National Institutes of Health (NIH) in the United States. 鈥淪he has been continuously working with world leaders in the development of new approaches and technologies,鈥� says Professor Vidal, 鈥渟o with her expertise and background, she could have gone anywhere. I do not think she would have come to 平特五不中 if the LSC was not as it is.鈥�

In the 10 years since the LSC has been up and running, the Complex Traits group, which in 2015 became the MRCCT, has produced several significantbreakthroughs.

A discovery by Professor of Biochemistry and Deputy Vice-Principal (Research and Innovation), Philippe Gros, one of the original researchers involved in the creation of the LSC, and his team that an older drug used to treat a rare kidney disordercalled cystinosis is effective as an adjuvant to treat malaria is now in clinical trial.

Professor Maya Saleh and her team have made important advances in our understanding of the interplay between innate immune response, cell death and inflammation in colitis, obesity and cancer among other conditions.

Professor J枚rg Fritz鈥榮 lab is closely examining a rare cell type present in lung tissues with the aim of better understating immune response in viral respiratory infections.

The LSC continues to seek new ways to improve and foster partnerships between investigators. One recent example is the popular series called LSC Talks Science, launched as part of the LSC鈥檚 10th anniversary celebrations as 鈥渁 new way to enhance and facilitate collaborations.鈥� Professor Vidal was inspired to initiate one such collaboration after the very first talk, by Assistant Professor of Physiology and member of the Cell Information Systems research theme . Professor Krishnaswamy, who prints his own equipment using a 3-D printer, is developing an instrument that will allow Professor Vidal鈥檚 lab to digitally and quantitatively measure the loss of mobility in mice used in multiple sclerosis research.

On the national scene, Professor Vidal is proud of the LSC鈥檚 collaboration with Mount Sinai and Sick Kids鈥� prestigious , which provides mouse model lab services to researchers across Canada and around the world. The 平特五不中 Research Centre on Complex Traits is responsible for platforms related to infection and inflammation.

PhD candidate Thiviya Jeyakumar feels lucky to work in this collaborative environment. 鈥淚 work on colitis-associated colorectal cancer,鈥� explains Ms. Jeyakumar, who is co-supervised by Professors of Biochemistry Philippe Gros and Nicole Beauchemin. 鈥淓ven though we鈥檙e all technically working on different types of inflammation and infectious diseases, because there are so many Principal Investigators and so many students there is enough overlap that you get to talk about what you鈥檙e doing, and borrow experiments and protocols. Everything flows so much easier.鈥�

Ms. Jeyakumar gives a lot of credit for these exchanges to the Complex itself. 鈥淭he lab bench space is an open space and, compared to other labs I鈥檝e seen, the layout works really well. The Complex really does benefit student research 鈥� I feel like that鈥檚 the predominant thing.鈥�

To read more about the Complex Traits theme and some of its research breakthroughs of the past 10 years, click here.