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Maryam Tabrizian

Title: 
Professor
Academic title(s): 

Maryam Tabrizian. PhD, MBA | Professor of Biomedical Engineering/Faculty of Medicine and Health Sciences, and Faculty of Dental Medicine and Oral Health Sciences

Canada Research Chair Tier-1 in Regenerative Medicine and Nanomedicine

Editor-in-Chief 鈥楳aterials鈥� MDPI

Associate Member of Bioengineering &听Experimental Surgery

Maryam Tabrizian
Contact Information
Phone: 
514-398-8129
Email address: 
maryam.tabrizian [at] mcgill.ca
Link(s): 
Biography: 

Maryam Tabrizian听is Canada Research Chair holder in Regenerative Medicine and Nanomedicine, cross-appointed between Faculty of Medicine-Biomedical Engineering Department and the Faculty of Dental Medicine and Oral Health Sciences. She was听the founding director of the Centre for Biorecognition and Biosensors (2003-2011) who has received many prestigious awards and fellowships (FRSQ-Chercheure nationale, Guggenheim foundation, Biomaterials Science & Engineering, RSC-Academy of Science, ADEA Leadership Institute, Canadian Academy of Health Sciences,..)听for her听contribution听to the field of Biomedical Engineering and Biomedical Sciences. She has听established听expertise in the design of advanced biomaterials and听biointerfaces听for their application in nanomedicine, regenerative medicine and Lab-on-a-chip devices. Professor Tabrizian is the author of over 235 peer-reviewed papers (H-index 63), 110 invited lectures,14 patents, and over 350 communications.

Research Interests

The development of novel interface for improved interaction of biomaterials with biological environment is the overall objective of our research. We aim at building a deeper understanding of cell-biomaterial interactions in order improve our ability to predict and control the host response to new material. This is carried out through design, fabrication and characterization of multifunctional and bioactive surfaces as well as developing methodologies and protocols for creating these new biointerfaces. Our motivation rises from our belief that the future of biomedical devices will exploit materials surfaces that are designed on the basis of engineering principles to mimic the way that nature does it. As such, our laboratory masters a broad expertise in surface modification techniques, namely chemical, molecular assembly and biological methods to cope with the highly divergent requirements for surface properties in biomedical applications. Our target applications are mainly focused on regenerative medicine, nanomedicine and Lab-on-a-Chip platforms.

Examples of our ongoing research activities:

  • Cell-cell and cell-biomaterial interactions.
  • Layer-by-Layer self-assembly as bioactive interface on artificial and biological nanoparticulate templates for imaging, molecular therapy and tissue engineering.
  • 3D and 2D biocompatible hydrogels and sponges for molecular therapy and tissue engineering.
  • Surface molecular engineering and nanopatterning for biorecognition systems
  • Microfluidic platform and Lab-on-a-Chip devices for genomic, proteomic, cell sorting and cell culturing.
  • Non-invasive and real-time assessment of cell and tissue growth in microenvironment 听
Areas of expertise: 
  • Biomaterials
  • Biointerface
  • Biorecognition
  • Regenerative medicine
  • Nanomedicine
  • Microfluidics-Lab on a Chip
  • Diagnostic tools
  • 听
Courses: 

BME 504 and DENT 504

Research areas: 
Biomaterials, Nanobiotechnology and Tissue Engineering
Awards, honours, and fellowships: 
  • Fellow of Canadian Academy of Health Sciences, 2020
  • Charles P Leblond award recipient, the Network for Oral and Bone Health Research, 2020
  • Canada Research Chair-Tier 1 in regenerative medicine and nanomedicine, 2019
  • American Dental Education Association (ADEA) Leadership Institute Fellow, 2019
  • Member of Europe Science Foundation (ESF): Community of expert, 2019
  • James 平特五不中 Professor, March 2018
  • Fellow of Royal Society of Canada-Academy of Science, 2017
  • Katz Excellence in Teaching Award, 平特五不中, 2017
  • Among the 6 finalists for David Thomson Award for Graduate Supervision and Teaching, 2017
  • International Fellow of the Biomaterials Science & Engineering (FBSE), 2011
  • Guggenheim Follow in Biomedical Sciences, 2010
  • FRQ-S Chercheure nationale (National Researcher Salary Award), 2006-2011
  • FRQ-S-chercheure boursi猫re (Salary Award), 2001-2006
Selected publications: 

Publications Last 6听Years (Trainee, *Corresponding Author)

196. T. Baudequin, C. Agnes, M. Tabrizian* (2021) "A Core-Shell Guanosine Diphosphate Crosslinked Chitosan Scaffold as a Potential Co-Encapsulation Platform", C, 256, 117499.

195. H. Salmon, M. R. Rasouli, N. Distasio, M. Tabrizian* (2020), 鈥淔acile engineering and interfacing of styrenic block copolymers for low-cost, multi-purpose microfluidic devices鈥�, Engineering Reports, Article ID: ENG212361, DOI: 10.1002/eng2.12361.

194. M. Singh, H. Nolan, M. Tabrizian, S. Cosnier, G. S. Duesberg and M. Holzinger* (2020), 鈥淔unctionalization of contacted Carbon Nanotube Forests by dip coating for high performing bio-cathodes鈥�, , 7(22) .

193. N. Distasio, H. Salmon, F. Dierick, T. Ebrahimian, M. Tabrizian*, S. Lehoux* (September 2020), "VCAM-1 targeted gene delivery nanoparticles localize to inflamed endothelial cells and atherosclerotic plaques", Advanced Therapeutics, .

  1. M. Yafia*, A. M. Foudeh, M. Tabrizian, H. Najjaran (2020), 鈥淟ow-cost graphene-based digital microfluidic system鈥�, micromachines-904641.

191. M. Yitayew, M. Tabrizian* (2020), "Hollow Microcapsules Through Layer-by-Layer Self-Assembly of Chitosan/Alginate on E. coli", MRS Advances, Cambridge University Press: 22 May 2020, pp. 1-7.

190. K. Jahan, G. Manickam, M. Tabrizian*, M. Murshed* (2020), 鈥淚n vitro and in vivo investigation of osteogenic properties of self-contained phosphate-releasing injectable purine-crosslinked chitosan-hydroxyapatite construct鈥�, Scientific Reports 10 (1), Article number: 9145.

189. M. Saad, D. Chinerman, M. Tabrizian, S. Faucher* (2020), 鈥淚dentification of two aptamers binding to Legionella pneumophila with high affinity and specificity鈥�, Scientific Report, Scientific Reports 10, Article number: 9145

188. P. Modarres, M Tabrizian* (2020), 鈥�Electrohydrodynamic-Driven Micromixing for the Synthesis of Highly Monodisperse Nanoscale Liposomes鈥�, ACS Appl. Nano Mater. 3(5):4000鈥�4013. .

187. P. Modarres, M Tabrizian* (2020), 鈥淧hase-controlled Field-effect Micromixing Using AC Electroosmosis", Microsystems & Nanoengineering (a nature publication) 6, Article number:60 (2020).

186. N. Watcharajittanont, M. Tabrizian, C. Putson, P. Pripatnanont, J. Meesane* (2020) 鈥淥sseointegrated membranes based on electro-spun TiO2/hydroxyapatite/poly-urethane for oral maxillofacial surgery鈥�, Mater Sci Eng C Mater Biol Appl, 108:110479.

185. M. Rasouli, M. Tabrizian* (2019), 鈥�Ultra-Rapid Acoustic Micromixer for Synthesis of Organic Nanoparticles", Lab Chip 19 (19), 3316 鈥� 3325.

184. F. R. Castiello, J. Porter, P. Modarres, M. Tabrizian* (2019), "Interfacial capacitance immunosensing using interdigitated electrodes: effect of the insulation/immobilization chemistry", Physical Chemistry Chemical Physics, 21, 15787鈥�15797.

183. S. Shoaib, M. Tabrizian* (2019), "A QCM-D biosensing strategy for investigating the real-time effects of oxidative stress on the viscoelastic properties of pre-osteoblast cells", Sensors & Actuators: B. Chemical, 293:235-24615.

182. L. Keller, Y. Idoux-Gillet, P. Schwint茅, L. Benameur, M. Tabrizian, P. Auvray, F. Bornert, D. Offner, R. M. Gonzalo-Daganzo, E. G贸mez Barrena, N. Benkirane-Jessel* (2019), "Preclinical safety study of a combined therapeutic bone wound dressing for osteoarticular regeneration", Nature Commun 10(1):2156.

181. S. Chen, A. Auriat, H Ismail, T. Li, A. Galuta, R. Sandarage, R. Wylie, D. X. B. Chen, S. Willerth, M. DeRosa, M. Tarizian, X. Cao, and E. C. Tsai* (2019), 鈥淎dvancements in Canadian Biomaterials and Implications for Neurotraumatic Diagnosis and Therapies鈥�, Processes,7:336; doi:10.3390/pr7060336.

180. F. R. Castiello, M. Tabrizian* (2019), "Gold nanoparticle amplification strategies for multiplex SPRi-based immunosensing of human pancreatic islet hormones", Analyst, 144(8):2541-2549.

179. P. Modarres, M. Tabrizian* (2019), 鈥淔requency Hopping Dielectrophoresis as a New Approach for Microscale Particle and Cell Enrichment鈥�, Sensors & Actuators: B. Chemical, 286:493-500.

178. K. Jahan, M. Mekhail, M. Tabrizian* (2019), 鈥淎 one-step fabrication of nanoapatite-chitosan scaffold as a potential soft and injectable construct for bone tissue engineering: An investigation of structural properties鈥�, Carbohydrate Polymers, 203(1):60-70.

177. N. DiStasio, M. Arts, S. Lehoux*, M. Tabrizian* (2018), 鈥淚L-10 Gene Transfection in Primary Endothelial Cells via Linear and Branched Poly(b-amino ester) Nanoparticles Attenuates Inflammation in Stimulated Macrophages鈥�, ACS-Appl. Bio Mater. 1(3):917鈥�927.

176. N. Distasio, S. Lehoux, A. Khademhosseini, M. Tabrizian* (2018), 鈥楾he Multifaceted Uses and Therapeutic Advantages of Nanoparticles for Atherosclerosis Research鈥�, Materials 2018, 11, 754; doi:10.3390/ma11050754.

175. R. Castiello, M. Tabrizian* (2018), 鈥淢ultiplex Surface Plasmon Resonance Imaging-Based Biosensor for Human Pancreatic Islets Hormones Quantification鈥� Anal Chem. 90(5):3132-3139.

174. S. Amrani, M. Tabrizian* (2018), 鈥淧assive Encapsulation and Characterization of Nanoscale Liposomes Produced by 2D Hydrodynamic Flow Focusing", ACS Biomater. Sci. Eng., 4(2):502鈥�513.

173. L. Benameur, T. Baudequin, M. Mekhail, M. Tabrizian* (2018), 鈥�The Bioconjugation Mechanism of Purine Cross-linkers Affects Microstructure and Cell Response to Ultra Rapidly Gelling Purine-Chitosan Sponges鈥�. Material Chemistry B. 6:602-613.

172. T. Baudequin, M. Tabrizian* (2018), 鈥�Multi-lineage Constructs for Scaffold-based Tissue Engineering: A review of Tissue-Specific Challenges鈥�, Adv Healthc Mater. 7(3):1-18.

171. P. Modarres, M. Tabrizian* (2017), 鈥�Alternating current dielectrophoresis of biomacromolecules: The interplay of electrokinetic effects鈥�, Sensors and Actuators B: Chemicals, 252:391-408.

170. S. Ghadakzadeh, R. C. Hamdy, M. Tabrizian* (2017), 鈥淓fficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis鈥�. Heliyon 3(11):e00450. doi: 10.1016/j.heliyon.

169. F. Melaine, M. Saad, S. Faucher, M. Tabrizian* (2017), 鈥淪elective and High Dynamic Range Assay Format for Multiplex Detection of Pathogenic Pseudomonas aeruginosa, Salmonella typhimurium, and Legionella pneumophila RNAs Using Surface Plasmon Resonance Imaging鈥�, Anal Chem. 89(14):7802-7807.

168. K. Heileman, M. Tabrizian* (2017), 鈥淒ielectric Spectroscopy Platform to Measure MCF10A Epithelial Cell Aggregation as a Model for Spheroidal Cell Cluster Analysis鈥�, Analyst, 42(9):1601-1607.

167. S. Filion-C么t茅, M. Tabrizian, A. G. Kirk* (2017), 鈥淩eal-Time Measurement of Complex Refractive Indices with Surface Plasmon Resonance鈥�, Sensors and Actuators B: Chemicals, 245:747-752.

166. S. Filion-C么t茅, A. G. Kirk, M. Tabrizian* (2017), 鈥淢onitoring of Bacterial Film Formation and their Breakdown with an Angular-Based Surface Plasmon Resonance Biosensor鈥�, Analyst, 42(13):2386-2394.

165. L. Nayef, R. Castiello, M. Tabrizian* (2017), 鈥淲ashless Method Enables Multilayer Coating of an Aggregation-Prone Nanoparticulate Drug Delivery System with Enhanced Yields, Colloidal Stability, and Scalability鈥�. Macromol Biosci. June 17(6). doi: 10.1002/mabi.201600535.

164. K. Heileman, J. Daoud, M. Tabrizian* (2016), 鈥淓laboration of a Finite Element Model of Pancreatic Islet Dielectric Response to Gap Junction Expression and Insulin Release鈥�, Colloids and Surfaces B: Biointerfaces, 148:474鈥�80.

163. O. Felfoul, M. Mohammadi, S. Taherkhani, D. de Lanauze, Y. Zhong Xu, D. Loghin, S. Essa, S. Jancik, D. Houle, M. Lafleur, L. Gaboury, M. Tabrizian, N. Kaou, M. Atkin, T. Vuong, G. Batist, N. Beauchemin, D. Radzioch, S. Martel* (2016), 鈥淢agneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions鈥�, Nature Nanotechnology, 11(11):941-947.

162. E. Samiei, M. Tabrizian, M. Hoorfar* (2016), 鈥淎 review of digital microfluidics as portable platforms for lab-on a-chip applications鈥�, Lab Chip, 16(13):2376-96.

161. S. Ghadakzadeh, M. Mekhail, A. Aoude, M. Tabrizian*, R. Hamdy* (2016), 鈥淪mall Players Ruling the Hard Game: siRNA in Bone Regeneration鈥�, J. Bone and Mineral Res., 31(3):475-487.

160. T. Nardo, V. Chiono, P. Gentile, M. Tabrizian, G. Ciardelli* (2016), 鈥淧oly(DL-lactide-co-蔚-caprolactone) and poly(DLlactide-co-glycolide) Blends for Biomedical Application: Physical Properties, Cell Compatibility, and in vitro Degradation Behavior, Int J Polymeric Materials and Polymeric Biomaterials, 65(16): 741-750.

159. R. Castiello, K. Heileman, M. Tabrizian* (2016), 鈥�Microfluidic perfusion systems for secretomic analysis: applications, challenges and opportunities for pancreatic islet research鈥�, Lab on a Chip, 16:409 - 431.

158. L. Nayef, M. Mekhail, L. Benameur, J. S. Rendon, R. Hamdy, M. Tabrizian* (2016), 鈥�A Combinatorial Approach towards Achieving an Injectable, Self-Contained, Phosphate-Releasing Scaffold for Promoting Biomineralization in Critical Size Bone Defects鈥�, Acta Biomaterialia. 1(29):389-97.

157. H. Khadivi Heris, S. Sheibani, J. Daoud, H. Vali, M. Tabrizian*, L. Mongeau* (2016), 鈥淚nvestigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration", Adv Healthcare Materials, 5(2):255-65 (inside front cover Vol. 5. No. 2. January 21. 2016).

156. S. Essa, J. Daoud, M. Lafleur, S. Martel, M. Tabrizian* (2015), "SN-38 active loading in poly(lactic-co-glycolic acid) nanoparticles and assessment of their anticancer properties on COLO-205 human colon adenocarcinoma cells" Journal of Microencapsulation, 32(8):784-93.

155. T. Nardo, V. Chiono, G. Ciardelli, M. Tabrizian* (2015), 鈥淧olyDOPA Mussel-Inspired Coating as a Means for Hydroxyapatite Entrapment on Polytetrafluoroethylene Surface for Application in Periodontal Diseases鈥�, Macromolecular Bioscience, 16(2):288鈥�298.

154. K. Jahan, M. Tabrizian* (2015), 鈥淐omposite Biopolymers for Bone Regeneration Enhancement in Bony Defects鈥�, Biomater. Sci., 4(1):25-39. (Advance Article).

153. K. Heileman, J. Daoud, C. Hasilo, M. Gasparrini, S. Paraskevas, M. Tabrizian* (2015), 鈥淢icrofluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy鈥�, Biomicrofluidics, 9, 044125.

152. J. Daoud, K. Heileman, S. Shapka, L. Rosenberg, M. Tabrizian* (2015), 鈥淒ielectric Spectroscopy for Monitoring Human Pancreatic Islet Differentiation within Cell-Seeded Scaffolds in a Perfusion Bioreactor System鈥�, Analyst 140, 6295 鈥� 6305.

151. R. Tien Sing Young, M. Tabrizian* (2015), 鈥淩apid, one-step fabrication and loading of nanoscale 1,2-distearoyl-sn-glycero-3-phosphocholine liposomes in a simple, double flow-focusing microfluidic device鈥�, Biomicrofluidics, 9(4):046501.

150. A. Foudeh, H. Trigui, N. Mendis, S. P. Faucher, T. Veres, M. Tabrizian* (2015), 鈥淩apid and Specific SPRi Detection of L. pneumophila in Complex Environmental Water Samples鈥�, Anal Bioanal Chemistry, 407(18):5541-45.

149. M. Singh, M. Holzinger*, M. Tabrizian, S. Winters, N.C. Berner, S. Cosnier*, G. S. Duesberg (2015), 鈥淣oncovalently functionalized monolayer graphene for sensitivity enhancement of surface plasmon resonance immunosensors鈥�, J Am Chem Soc. 137(8):2800-3.

148. A. M. Foudeh, D. Brassard, M. Tabrizian, T. Veres* (2015), 鈥�Rapid and multiplex detection of Legionella's RNA using digital microfluidics鈥�, Lab on a Chip. 15(6):1609-18.

147. M. Mekhail, G. Almazan, M. Tabrizian* (2015), 鈥�Purine-Crosslinked Injectable Sponges Promote Oligodendrocyte Progenitor Cells Attachment and Differentiation鈥�, Biomaterials Science, 3(2), 279-287.

146. M. Singh, M. Holzinger, M. Tabrizian, S. Cosnier* (2015), 鈥淟ayer by layer scaffold formation using magnetic attraction between HiPCO庐 single-walled carbon nanotubes and magnetic nanoparticles: application for high performance immunosensors鈥� CARBON, 81: 1731 鈥�738.

145. F. Tzelepis, J. Daoud, M. Verway, J. Gillard, K. Hassani-Ardakani, J. Jaworska, Y. N茅d茅lec, H. Vali, M. Tabrizian, L. Barreiro, M. Divangahi* (2015), 鈥淎nnexin 1 is critical in immunity to Mycobacterium tuberculosis infection by mediating DC, efferocytosis and antigen cross-presentation鈥�, Journal of Clinical Investigation, 125(2):752-768.

. nih.gov/pmc/articles/PMC4319406/pdf/JCI77014.pdf

144. C. Holmes, M. Tabrizian, P. O. Bagnaninchi* (2015), 鈥淢otility imaging via optical coherence phase microscopy enables label-free monitoring of tissue growth and viability in 3D tissue engineering scaffolds", J Tissue Eng and Regenerative Medicine 9(5):641-645.

143. S. Filion-C么t茅 S, P. J. Roche, A. Foudeh, M. Tabrizian, A. G. Kirk* (2014), 鈥淒esign and analysis of a spectra-angular surface plasmon resonance biosensor operating in the visible spectrum鈥�, Rev Sci Instrum, 85(9):093107.

142. L. Nayef, J. S. Rendon, R. Matthys, R. C. Hamdy, M. Tabrizian* (2014), 鈥淟iposome Encapsulated Quantum Dots Show Efficient In Vivo Retention of a Nanoparticulate Drug Delivery System at its Target in a Rat model of Distraction Osteogenesis鈥�, Journal of Nanopharmaceutics and Drug Delivery, 2(2), 93-102.

141. S. Martel*, S. Taherkhani, M. Tabrizian, M. Mohammadi, D. de Lanauze, O. Felfoul (2014), 鈥淐omputer 3D Controlled Bacterial Transports and Aggregations of Microbial Adhered Nano-components鈥� Journal of Micro-Bio Robotics, 9():23-28.

140. K. Bowey, J. F. Tanguay, M.G. Sandros, M. Tabrizian* (2014), 鈥淢icrowave-assisted synthesis of surface-enhanced Raman scattering nanoprobes for cellular sensing鈥�, Colloids Surf B Biointerfaces, 122:617-22.

139. S. Saha, C. Tomaro-Duchesneau, L. Rodes, M. Malhotra, M. Tabrizian and S. Prakash* (2014), 鈥淚nvestigation of probiotic bacteria as dental caries and periodontal disease biotherapeutics鈥�, Beneficial Microbes, 8:1-14.

138. A. M. Makhdom, L. Nayef, M. Tabrizian*, R. C. Hamdy (2014), 鈥�The Potential Roles of Nanobiomaterials in Distraction Osteogenesis鈥�, NanoMed-Nanotech Biolog. Med. 11(1):1-18.

137. S. Taherkhani, M. Mohammadi, , S. Martel, M. Tabrizian* (2014), 鈥淐ovalent Binding of Nanoliposomes to the Surface of Magnetotactic Bacteria for the Synthesis of Self Propelled Therapeutic Agents", ACS Nano, 8(5):5049-60.

136. M. Mekhail, K. Jahan, M. Tabrizian* (2014), 鈥淕enipin-crosslinked two-dimensional Chitosan/Poly-L-lysine gels promote Fibroblast adhesion and proliferation鈥�, Carbohydrate Polymers, 108:91-8.

135. M. Mekhail, M. Tabrizian* (2014), 鈥�Injectable Chitosan-Based Scaffolds in Regenerative Medicine and their clinical translatability鈥�, Adv Healthcare Materials, 3(10):1529-45.

134. C. Holmes, J. Daoud, P. O. Bagnaninchi, M. Tabrizian* (2014), 鈥淧olyelectrolyte multilayer coating of 3D scaffolds enhances tissue growth and gene delivery: Non-invasive and label-free assessment鈥�. Adv Healthcare Materials, 3(4):572鈥�80.

133. K. Bowey, J-F. Tanguay, M. Tabrizian* (2014), 鈥�2-Dioleoyl-sn-Glycero-3-Phosphocholine-Based Liposomal Nanoparticles as an Effective Delivery Platform for 17beta-Estradiol鈥�, Eur J Pharmaceutics and Biopharmaceutics, 86(3):369-75.

132. A. M. Foudeh, J. Daoud, S. Faucher, T. Veres, M. Tabrizian* (2014), 鈥淪ub-femtomole Detection of 16s rRNA from Legionella pneumophilia Using Surface Plasmon Resonance Imaging Through a Designed Post-amplification Methodology鈥�, Biosensors and Bioelectronics 52:129-35.

131. T. Fatanat Didar, K. Bowey, G. Almazan, M. Tabrizian* (2014), 鈥淎 miniaturized multipurpose platform for rapid, label-free and simultaneous separation, patterning and in vitro culture of primary and rare cells鈥�, Adv Healthcare Materials, 3(2):253-60.

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