平特五不中

Biosensors promise to impact many fields ranging from basic research of biological systems to the development of biomedical devices poised to revolutionize modern healthcare. The number of methods for developing biosensors continues to grow at an impressive rate representing the cutting-edge interface of chemistry and many other fields. This talk takes a step back to understand the fundamentals of sensor performance of a class of bio-inspired electrochemical sensors using functional nucleic acids or membrane proteins. We utilize a combination of electrochemistry, biochemistry, and biomolecular design and engineering to build better biosensors and imaging platforms. By developing models for the electrochemical response and understanding the structure and function of nucleic acids (e.g., aptamers) and proteins (e.g., ion channels) we can tune the response of a sensor based on the bioanalytical application of the sensor. Coupling these sensors with micro- and nanoscale electrodes further enables us to tune sensor performance for applications ranging from molecular flux imaging, single-cell analysis to implantable devices for real-time therapeutic monitoring.