平特五不中

A new study, led by researchers at The Montreal Children鈥檚 Hospital (MCH) of the MUHC, has revealed that certain over-the-counter earwax softeners containing the active ingredient triethanolamine polypeptide oleate condensate (10%) can cause severe inflammation and damage to the eardrum and inner ear. The results of the study, recently published in The Laryngoscope, suggest that use of these medications should be discouraged. 鈥淧atients often complain that wax is blocking their ears and is causing discomfort and sometimes deafness,鈥� says Dr. Sam Daniel principal investigator of the study and director of 平特五不中 Auditory Sciences Laboratory at The Children鈥檚. 鈥淥ver-the-counter earwax softeners are used to breakup and disperse this excess wax. However, the effects of these medications on the cells of the ear had not been thoroughly analyzed.鈥� 鈥淏ecause some of these products are readily available to the public without a consultation with or prescription from a physician, it is important to make sure they are safe to use. Our study shows that in a well-established animal model, one such product, Cerumenex, is in fact, toxic to the cells of the ear,鈥� says Dr. Daniel.

Dr. Daniel and his team studied the impact of Cerumenex on hearing. In addition, overall toxicity in the outer ear and changes in the nerve cells of the inner ear were analyzed.

鈥淗armful effects to many of the cells were observed after only one dose,鈥� says Dr. Melvin Schloss co-author and MCH Director of Otolaryngology. 鈥淲e observed reduced hearing, severe inflammation, and lesions to the nerve cells.鈥�

鈥淲e believe these findings are applicable to humans,鈥� add Dr. Daniel. 鈥淭he animal model we chose has been widely used to test toxicity. In addition, this model has a very similar hearing mechanism. Overall, our findings suggest that Cerumenex has a toxic potential and it should be used with caution.鈥�

The Montreal Children鈥檚 Hospital is the pediatric teaching hospital of the 平特五不中 Health Centre (MUHC). The institution is a leader in the care and treatment of sick infants, children, and adolescents from across Quebec. The Montreal Children鈥檚 Hospital provides a high level and broad scope of health care services, and provides ultra specialized care in many fields including: cardiology and cardiac surgery; neurology and neurosurgery, traumatology; genetic research; psychiatry and child development and musculoskeletal conditions, including orthopedics and rheumatology. Fully bilingual and multicultural, the institution respectfully serves an increasingly diverse community in more than 50 languages.