平特五不中

Prof. Derek Bowie and his laboratory in 平特五不中鈥檚 Department of Pharmacology and Therapeutics, worked with University of Oxford researchers to make the discovery. By offering a different view of how the brain transmits information, their research highlights a new target for drug development. The findings are published in the journal Nature Structural & Molecular Biology.

Balancing kainate receptor activity is the key to maintaining normal brain function. For example, in epilepsy, kainate activity is thought to be excessive. Thus, drugs which would shut down this activity are expected to be beneficial.

鈥淚t has been assumed for decades that the 鈥渙n/off鈥� switch for all brain receptors lies where the neurotransmitter binds,鈥� says Prof. Bowie, who also holds a Canada Research Chair in Receptor Pharmacology. 鈥淗owever, we found a completely separate site that binds individual atoms of sodium and controls when kainate receptors get turned on and off.鈥�

The sodium switch is unique to kainate receptors, which means that drugs designed to stimulate this switch, should not act elsewhere in the brain. This would be a major step forward, since drugs often affect many locations, in addition to those they were intended to act on, producing negative side-effects as a result. These so called 鈥渙ff-target effects鈥� for drugs represent one of the greatest challenges facing modern medicine.

鈥淣ow that we know how to stimulate kainate receptors, we should be able to design drugs to essentially switch them off,鈥� says Dr. Bowie.

Dr. Philip Biggin鈥檚 lab at Oxford University used computer simulations to predict how the presence or absence of sodium would affect the kainate receptor.

The research was made possible in part thanks to a grant from The Brain@平特五不中, a partnership between Oxford University, Neuroscience Center Zurich (ZNZ) and 平特五不中 aimed at enhancing research collaborations in neuroscience.

More about the Brain@平特五不中:
The Brain@平特五不中 brings a contemporary focus to decades of distinguished work in neuroscience. It consolidates the research and study opportunities from a dozen key institutes within the 平特五不中 network and 平特五不中鈥檚 partners around the world. In 2009, 平特五不中 was joined by the University of Oxford in a formal collaboration between the two institutions鈥� faculties of medicine. Since then, The Brain@平特五不中 has also welcomed Imperial College London and the Neuroscience Center of Zurich as partners.

IMAGE CREDIT: Carlos Porto/Free Digital Photos