ƽÌØÎå²»ÖÐ

OurÌýPET Unit offers cutting-edge nuclear imaging technology and expertise to all investigators, including:Ìý

1. ​the conception and production of PET radiopharmaceuticals under conditions that satisfy all Health-Canada and nuclear safety regulations,
2. high-quality imaging ofÌýdisease models ²¹²Ô»åÌýhuman participants

We feature the largest catalog of tracers in Canada, that areÌýall produced onsite in our research-dedicated cyclotron and radiochemistry laboratory. New compounds can be produced on demand. We provide the scanning technology and expertise forÌýhigh-resolution imaging of the smallest brain regions, with high quantitative accuracy. Our core scanning facility is equipped with a Siemens HRRT, the PET camera with the highest-spatial resolution available (one of the 14 installed worldwide), a Siemens HR+ scanner and a SPECT camera. Ìý

To get your PET study started and all other related inquiries, please contact the PET Medical Director (protocol) or the Director of Cyclotron (production of existing and new tracers).

PET Unit Staff

Ìý

Our PET and Cyclotron staff is supported in part by a generous donation from the Louise and Alan Edwards Foundation.

Ìý

Ìý

Animal PET

We offer access to a CTI Concorde microPET R4 scanner for PET imaging of small-animals. Combined with our 7-T small-bore MRI scanner, our on-site cyclotron, radiochemistry, and HPLC facilities, we offer the best service to develop functional and molecular imaging of disease models.

PET TracersÌý

Please contact the Gassan.Massarweh [at] mcgill.ca (subject: Production%20of%20PET%20Tracers) (Director of Cyclotron) to inquire about the production of other tracers not featured in the list.

¹¹C-ABP688 (3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-¹¹C-methyl-oxime)

Highly selective antagonist tracer for imaging the metabotropic glutamate receptor subtype 5 (mGluR5)

¹¹C-DTBZ (dihydrotetrabenazine)

High-affinity ligand of the vesicular monoamine transporter (VMAT2)

¹¹C-PIB ( N-methyl-[¹¹°ä±Õ2-(4′-³¾±ð³Ù³ó²â±ô²¹³¾¾±²Ô´Ç±è³ó±ð²Ô²â±ô)-6-³ó²â»å°ù´Ç³æ²â²ú±ð²Ô³ú´Ç³Ù³ó¾±²¹³ú´Ç±ô±ð)

beta-Amyloid binding agent for imaging amyloid plaques

¹¹C-Raclopride

Dopamine D2 receptor antagonist

¹¹C-SCH 23390

Dopamine D1 receptor antagonist

¹⁸F-fallypride

Dopamine D2 receptor antagonist with high affinity, allowing cortical D2r visualisation

¹¹C-PK 11195

Ligand of the mitochondrial Translocator Protein (TSPO; formerly designated as the peripheral benzodiazepine receptor), found in activated microglia (inflammation marker)

¹⁸F-PBR06 ([¹⁸F]Imidazo[1,2-a]pyridine)

Also a ligand of the mitochondrial Translocator Protein (TSPO; formerly designated as the peripheral benzodiazepine receptor), found in activated microglia (inflammation marker). Shows less non-specific binding than ¹¹C-PK 11195, and is labelled with ¹⁸F, allowing for more widespread distribution.

¹⁸F-MPPF

Ligand of the serotonin receptor 5-HT1A; agonist

¹⁸F-Altanserin

Ligand of the serotonin receptor 5-HT2A; agonist

¹⁸F-Benzovesamicol

Radioligand of the vesicular acethylcoline transporter (VAChT). Still investigational (used in only models at this time)

¹⁸F-FDG (2-deoxy-2-[¹⁸F]fluoro-D-g1ucose)

Glucose analog

¹⁸F-Flumazenil

Ligand of the benzodiazepine receptor (cBZR) found on gamma-aminobutyric acid (GABA-A) receptors

¹⁸F-SFB (N-succinimidyl 4-[¹⁸F]fluorobenzoate)

Can be used for labelling a variety of peptides and proteins with wide-ranging targets specificity

¹⁸F-NAV4694

beta-Amyloid binding agent for imaging amyloid plaques

¹⁵O water

Ìý[¹⁵O]water is used for measuring regional cerebral blood flow

¹⁸F-FMISO

Fluoromisonidazole for the detection of hypoxia

¹⁸F-FMCh,Ìý[¹⁸F]Fluoromethyl-[1,2-²H₄]-choline

A novel radiotracer for imaging choline metabolism in tumors

¹⁸F-FECh,Ìý2-[(18)F]Fluoroethyl-choline ([(18)F]FECH)Ìý

A tracer for the detection of prostate cancer

¹¹C-FLB 457

For imaging D2 dopamine receptors in extrastriatal brain regions

¹⁸F-Flurpiridaz

PET myocardial perfusion imaging (perfusion agent from Lantheus0

¹⁸F-T807

PET imaging agent for Tau